202 research outputs found
Detecting single-trial EEG evoked potential using a wavelet domain linear mixed model: application to error potentials classification
Objective. The main goal of this work is to develop a model for multi-sensor
signals such as MEG or EEG signals, that accounts for the inter-trial
variability, suitable for corresponding binary classification problems. An
important constraint is that the model be simple enough to handle small size
and unbalanced datasets, as often encountered in BCI type experiments.
Approach. The method involves linear mixed effects statistical model, wavelet
transform and spatial filtering, and aims at the characterization of localized
discriminant features in multi-sensor signals. After discrete wavelet transform
and spatial filtering, a projection onto the relevant wavelet and spatial
channels subspaces is used for dimension reduction. The projected signals are
then decomposed as the sum of a signal of interest (i.e. discriminant) and
background noise, using a very simple Gaussian linear mixed model. Main
results. Thanks to the simplicity of the model, the corresponding parameter
estimation problem is simplified. Robust estimates of class-covariance matrices
are obtained from small sample sizes and an effective Bayes plug-in classifier
is derived. The approach is applied to the detection of error potentials in
multichannel EEG data, in a very unbalanced situation (detection of rare
events). Classification results prove the relevance of the proposed approach in
such a context. Significance. The combination of linear mixed model, wavelet
transform and spatial filtering for EEG classification is, to the best of our
knowledge, an original approach, which is proven to be effective. This paper
improves on earlier results on similar problems, and the three main ingredients
all play an important role
Asymptotic Behaviour of Reduced-Order Filters
Reduced-order filters are proposed for linear and nonlinear systems and their long time behaviour is studied. Using the results of Ocone and Pardoux \cite{ocpa} on the asymptotic stability of the optimal filter with respect to its initial condition, the asymptotic efficiency of these filters is established in various cases
Asymptotic Optimality of Approximate Filters in Stochastic Systems with Colored Noises
In this report, a new interpretation of the main part of our study on asymptotic behaviour of reduced-order filters in [6] is given. Approximate filters are proposed for semi-linear and nonlinear stochastic systems with colored noises. Basically these filters are defined as those which are optimal when the noises are white. Their long time behavior is investigate- d and their asymptotic optimality is shown in two cases under some reasonable assumptions. At first the case of a system where the signal and observation dynamics are linear with respect to the state is considered; the approximate filter is a Kalman filter and the asymptotic analysis relies on a representati- on of the optimal filter which extends a formula known for a linear system with white noises and non-Gaussian initial condition. Then the case of a nonlinear system with limiting ergodic behavior is analyzed; here the approximate filter appears as the optimal filter corresponding to an incorrect prior distribution and the asymptotic study uses the results of Ocone and Pardoux on the asymptotic stability of optimal filters with respect to their initial condition
An Elementary Approach to Filtering in Systems with Fractional Brownian Observation Noise
The problem of optimal filtering is addressed for a signal observed through a possibly nonlinear channel driven by a fractional Brownian motion. An elementary and completely self-contained approach is developed. An appropriate Girsanov type result is proved and a process -- equivalent to the innovation process in the usual situation where the observation noise is a Brownian motion -- is introduced. Zakai's approach is partly extended to derive filtering equations when the signal process is a diffusion. The case of conditionally Gaussian linear systems is analyzed. Closed form equations are derived both for the mean of the optimal filter and the conditional variance of the filtering error. The results are explicit in various special cases
Big Data Analytics and Organizational Culture as Complements to Swift Trust and Collaborative Performance in the Humanitarian Supply Chain
International audienc
Culex pipiens, an Experimental Efficient Vector of West Nile and Rift Valley Fever Viruses in the Maghreb Region
West Nile fever (WNF) and Rift Valley fever (RVF) are emerging diseases causing epidemics outside their natural range of distribution. West Nile virus (WNV) circulates widely and harmlessly in the old world among birds as amplifying hosts, and horses and humans as accidental dead-end hosts. Rift Valley fever virus (RVFV) re-emerges periodically in Africa causing massive outbreaks. In the Maghreb, eco-climatic and entomologic conditions are favourable for WNV and RVFV emergence. Both viruses are transmitted by mosquitoes belonging to the Culex pipiens complex. We evaluated the ability of different populations of Cx. pipiens from North Africa to transmit WNV and the avirulent RVFV Clone 13 strain. Mosquitoes collected in Algeria, Morocco, and Tunisia during the summer 2010 were experimentally infected with WNV and RVFV Clone 13 strain at titers of 107.8 and 108.5 plaque forming units/mL, respectively. Disseminated infection and transmission rates were estimated 14–21 days following the exposure to the infectious blood-meal. We show that 14 days after exposure to WNV, all mosquito st developed a high disseminated infection and were able to excrete infectious saliva. However, only 69.2% of mosquito strains developed a disseminated infection with RVFV Clone 13 strain, and among them, 77.8% were able to deliver virus through saliva. Thus, Cx. pipiens from the Maghreb are efficient experimental vectors to transmit WNV and to a lesser extent, RVFV Clone 13 strain. The epidemiologic importance of our findings should be considered in the light of other parameters related to mosquito ecology and biology
Directional control of weakly localized Raman from a random network of fractal nanowires
Disordered optical media are an emerging class of materials capable of
strongly scattering light. Their study is relevant to investigate transport
phenomena and for applications in imaging, sensing and energy storage. While
such materials can be used to generate coherent light, their directional
emission is typically hampered by their very multiple scattering nature. Here,
we tune the out-of-plane directionality of coherent Raman light scattered by a
fractal network of silicon nanowires. By visualizing Rayleigh scattering,
photoluminescence and weakly localized Raman light from the random network of
nanowires via real-space microscopy and Fourier imaging, we gain insight on the
light transport mechanisms responsible for the material's inelastic coherent
signal and for its directionality. The possibility of visualizing and
manipulating directional coherent light in such networks of nanowires opens
venues for fundamental studies of light propagation in disordered media as well
as for the development of next generation optical devices based on disordered
structures, inclusive of sensors, light sources and optical switches
Current therapy of granulomatosis with polyangiitis and microscopic polyangiitis: the role of rituximab.
Granulomatosis with polyangiitis and microscopic polyangiitis are anti-neutrophil cytoplasmic antibody-associated vasculitides (AAVs) that are prone to cycles of remission and relapse. The introduction of cytotoxic therapy has changed the prognosis for these diseases from typically fatal to manageable chronic illnesses with a relapsing course. Despite improvements in outcomes, recurrence of disease and drug-related toxicity continue to produce significant morbidity and mortality. Better understanding of the pathogenesis of AAV and the mechanism of action of cyclophosphamide has led to investigation of therapies that target B cells. Two randomized controlled trials have shown that rituximab is not inferior to cyclophosphamide for induction of remission in severe AAV, with no significant difference in the incidence of overall adverse events in rituximab- versus cyclophosphamide-treated patients. Data from ongoing clinical trials will determine the role of rituximab in the maintenance of remission
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